We propose a new technique, contactless differential conductivity detection (CDCD,) to improve the detection limit of contactless conductivity detection for capillary and microchannel electrophoresis. By exploiting a 3-electrode differential configuration, CDCD greatly reduces the dominant noise source in contactless conductivity detection: temperature fluctuations within the measurement system. This will be a particularly important feature for high-conductivity samples, which are most susceptible to thermal noise. The reduced sensitivity of CDCD to temperature fluctuations and its potential suitability for low-power operation will also make this an excellent candidate for field-portable and point-of-application uses where optical detection strategies may be more difficult to implement.
Proceedings Title: Proceedings of microTAS 2008
Conference Dates: October 12-16, 2008
Conference Location: San Diego, CA
Conference Title: microTAS 2008
Pub Type: Conferences
contactless conductivity detection, detector, electrophoresis