Comparison of Strength Properties of Normotensive and Hypertensive Rat Pulmonary Arteries

Published

October 1, 2004

Author(s)

Elizabeth S. Drexler, Christopher N. McCowan, J Wright, Andrew J. Slifka, Dunbar Ivy, Robin Shandas

Abstract

A series of tests were conducted to quantify the difference in the mechanical properties of normo-and hypertensive pulmonary arteries. A bubble-test design was emplpoyed to measure the biaxial properties of a segment of artery. The test results compare the properties at multiple orientations of the grunk, right, and left pulmonary arteries from normal (Control) and monocrotaline-treated male Long-Evans wild rats that ranged in age from 8 to 17 weeks old, along with some preliminary results from hypoxic Long-Evans knock-out rats. Data show littaline-treated pulmonary arteries. However, the preliminary results from the hypoxic pulmonary arteries show that the arterial material strains less before the onset of strain-stiffening behavior. The longitudinal orientation exhibits strain stiffening at lower strains than the circumferential orientation. The difference between the left and right main arteries are minor. The trunk consistently demonstrates less stiffening in the region of larger strains for all conditions.

Proceedings Title

Annual Rocky Mountain Bioengineering Symposium|41st|Biomedical Sciences Instrumentation|Instrument Society of America

Volume

40

Conference Dates

April 1, 2004

Conference Title

Proceedings of the Rocky Mountain Bioengineering Symposium

Pub Type

Conferences

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Keywords

hypertension, hypoxia, monocrotaline, pulmonary artery, rat, strain, strength, stress

Citation

Drexler, E. , McCowan, C. , Wright, J. , Slifka, A. , Ivy, D. and Shandas, R. (2004), Comparison of Strength Properties of Normotensive and Hypertensive Rat Pulmonary Arteries, Annual Rocky Mountain Bioengineering Symposium|41st|Biomedical Sciences Instrumentation|Instrument Society of America, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=851344 (Accessed April 25, 2024)