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Challenges and advances in the application of dynamic nuclear polarization to liquid-state NMR spectroscopy
Published
Author(s)
Nandita Abhyankar, Veronika Szalai
Abstract
Dynamic nuclear polarization (DNP) can overcome the relatively low sensitivity of nuclear magnetic resonance (NM) spectroscopy by using a paramagnetic matrix to hyperpolarize a nuclear spin ensemble. Application of DNP-NMR results in sensitivity gains of up to four orders of magnitude compared to NMR without DNP. Although DNP-NMR is now more routinely available for solid-state NMR spectroscopy, it has not been exploited to the same degree for liquid samples. This review will consider challenges and advances in the application of DNP NMR to solution-state samples. The review is organized into four sections including (i) applications of DNP-NMR for volume-limited/mass-limited samples; (ii) mechanisms of DNP NMR; (iii) available detection schemes and challenges for liquid-state samples; and (iv) instrumental challenges and the outlook for liquid-state DNP NMR.
Abhyankar, N.
and Szalai, V.
(2021),
Challenges and advances in the application of dynamic nuclear polarization to liquid-state NMR spectroscopy, Journal of Physical Chemistry B, [online], https://doi.org/10.1021/acs.jpcb.0c10937, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=931486
(Accessed October 10, 2025)