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Challenges and advances in the application of dynamic nuclear polarization to liquid-state NMR spectroscopy

Published

Author(s)

Nandita Abhyankar, Veronika Szalai

Abstract

Dynamic nuclear polarization (DNP) can overcome the relatively low sensitivity of nuclear magnetic resonance (NM) spectroscopy by using a paramagnetic matrix to hyperpolarize a nuclear spin ensemble. Application of DNP-NMR results in sensitivity gains of up to four orders of magnitude compared to NMR without DNP. Although DNP-NMR is now more routinely available for solid-state NMR spectroscopy, it has not been exploited to the same degree for liquid samples. This review will consider challenges and advances in the application of DNP NMR to solution-state samples. The review is organized into four sections including (i) applications of DNP-NMR for volume-limited/mass-limited samples; (ii) mechanisms of DNP NMR; (iii) available detection schemes and challenges for liquid-state samples; and (iv) instrumental challenges and the outlook for liquid-state DNP NMR.
Citation
Journal of Physical Chemistry B
Volume
125
Issue
20

Keywords

dynamic nuclear polarization, nuclear magnetic resonance, solution state NMR

Citation

Abhyankar, N. and Szalai, V. (2021), Challenges and advances in the application of dynamic nuclear polarization to liquid-state NMR spectroscopy, Journal of Physical Chemistry B, [online], https://doi.org/10.1021/acs.jpcb.0c10937 (Accessed July 3, 2022)
Created May 7, 2021, Updated February 23, 2022