Green, A.
, Camara, J.
and Heckert, N.
(2025),
Certification of Standard Reference Material® 3666: Albumin and Creatinine in Frozen Human Urine - INCLUDES UPDATES AS OF 12-15-2025, Special Publication (NIST SP), National Institute of Standards and Technology, Gaithersburg, MD, [online], https://doi.org/10.6028/NIST.SP.260-238-upd3 (Accessed August 20, 2026)
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Certification of Standard Reference Material® 3666: Albumin and Creatinine in Frozen Human Urine - INCLUDES UPDATES AS OF 12-15-2025
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Abstract
The National Institute of Standards and Technology (NIST) Standard Reference Material® (SRM®) 3666 Albumin and Creatinine in Frozen Human Urine is a secondary measurement standard for albumin and creatinine in human urine. The material is intended for use in a calibration hierarchy, in the validation of measurement procedures, or as quality control material for the determination of albumin, creatinine, or the albumin-to-creatinine ratio (ACR) in human urine. A unit of SRM 3666 consists of four (4) vials of frozen pooled human urine with four (4) different levels (Level I to Level IV) of endogenous albumin determined using the NIST candidate reference measurement procedure (RMP) for albumin in urine; and creatinine determined using a modification of the NIST RMP for creatinine in serum. The certified values and associated uncertainties for albumin and creatinine were used to calculate the ACR for each level (Level I to Level IV). This publication documents the production, measurement processes, results, and statistical evaluations involved in the production and certification of SRM 3666.Citation
Special Publication (NIST SP) - 260-238-upd3
Report Number
260-238-upd3
NIST Pub Series
Pub Type
NIST Pubs
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Keywords
Albumin, Albumin-to-Creatinine Ratio (ACR), Creatinine, Human Urine, Reference Measurement Procedure (RMP), Standard Reference Material (SRM)
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Created December 15, 2025, Updated August 19, 2026