In the biological sciences, there is an increasing need for measurement tools that can provide high-throughput, high-quality data (consider drug discovery and systems biology, for example). Capillary electrophoresis (CE) is fast, requires only small amounts of sample and reagents, and can be applied to a wide variety of biochemical analysis problems. In addition, capillary array electrophoresis systems have been described for high throughput operation. However, one obstacle to the wider application of high throughput CE is the complexity and high cost of capillary array instruments and techniques.
Develop a new method for multiplexed capillary electrophoresis that is simpler and less expensive than conventional technologies.
- Determine the simplest possible device that can be used for electrophoretic assays
- Determine parameters and design rules for optimization of device performance
- Develop methods for device fabrication and operation
- Demonstrate use of device for high-throughput biochemical assays