Bringing new products to market requires measurements for rapid, quantitative assessment of composition and structure. To this end, NIST has developed a series of mass spectrometry-based tools that decrease the time necessary to achieve measurement success while producing more accurate results. The development of our tools and techniques has been guided by the needs of U.S. industry through our series of annual workshops as well as our active participation in the Versailles Project on Advanced Materials and Standards (VAMAS).
|Examples of our unique tool set include the MassSpectator computer code for automated, unbiased peak integration of mass spectral data; software for numerical optimization of instrument parameters; sample preparation methods employing aerosol deposition of analytes to ensure robust, reproducible experimental results; and a mass spectrometer that enables melting of samples during analysis. Our Taylor's Expansion Method for determining absolute molecular mass distribution of macromolecules and nanoparticles is a milestone in quantitative mass spectrometry of polydisperse materials. The unique mass spectrometer, custom-made sample preparation devices, and computer code developed in our laboratories are themselves prototypes for potential future products.|