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Zvi Kelman (Fed)

Research Biologist

Zvi is the director of the Biomolecular Labeling Laboratory (BL2) at the National Institute of Standards and Technology (NIST). He is also a Fellow at the Institute for Bioscience and Biotechnology Research (IBBR) and an adjunct Professor at Department of Cell Biology and Molecular Genetics, University of Maryland, College Park.  He is also affiliated with the Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine and he is a member of the Biological Science (BISI) program at the University of Maryland, College Park, the Marine Estuarine Environmental Sciences (MEES), University of Maryland and the Program in Oncology, University of Maryland School of Medicine. 

 

 
Zvi earned a B.Sc. in Agriculture from the Hebrew University in Jerusalem and a M.Sc. in Cell Biology from the Weizmann Institute of Science.   After receiving a Ph.D. in Molecular Biology from the Cornell University Graduate School of Medical Sciences, he was a Helen Hay Whitney Foundation Post-Doctoral Fellow in the laboratories of Thomas Kelly (Johns Hopkins University) and Jerard Hurwitz (Memorial Sloan-Kettering Cancer Center). Upon completion of his postgraduate training, he became a Life Technologies Professor at the Center for Advanced Research in Biotechnology (CARB), University of Maryland Biotechnology Institute (UMBI).  Dr. Kelman moved to the University of Maryland, College Park in 2010 and to his current position at NIST in 2011.

Awards

2022, Extremophiles2022 VIP meeting, Greece

2021, NIST MML Technical Excellence Accolade - Collaboration and Teamwork Accolade

2020, Department of Commerce Gold Medal Award

2020, NIST MML Technical Excellence Accolade - Collaboration and Teamwork Accolade

2017, NIST MML Cross-Division/Cross-OU Teamwork Accolade

2013, Japan Society for the Promotion of Science (JSPS) Invitation Fellowship Program

 

Publications

Effects of Glycans and Hinge on Dynamics in the IgG1 Fc

Author(s)
Christina Bergonzo, J. Todd Hoopes, Zvi Kelman, David Travis Gallagher
The crystallizable fragment (Fc) domain of immunoglobulin subclass IgG1 antibodies is engineered for a wide variety of pharmaceutical applications. Two
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Patents (2018-Present)

Amino Acid-Specific Binder And Selectively Identifying An Amino Acid

NIST Inventors
John P. Marino and Zvi Kelman
N-terminal amino acid binding (NAAB) reagents are a tool for parallel, high-throughput proteomics. Afluorescently-labeled NAAB allows immobilized peptides to be identified by their N-terminal residues using single-molecule fluorescent microscopy, which enables novel proteomic analysis, like

Di-enzymatic Chimeric Endolysin

NIST Inventors
Zvi Kelman
Bacteriophage-derived endolysins have great potential as alternative antimicrobial agents for Gram-positive bacterial infectious diseases, as they are peptidoglycan hydrolases that can destroy susceptible bacteria when applied exogenously. Due to the modular structure of endolysins, engineering

Amino Acid-specific Binder and Selectively Identifying an Amino Acid

NIST Inventors
Zvi Kelman and John P. Marino
One of the central challenges in the development of single-molecule protein sequencing technologies is achieving high- fidelity, sequential recognition and detection of specific amino acids that comprise the peptide sequence. The N-End Rule Pathway adaptor protein ClpS, natively recognizes N
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Created June 18, 2019, Updated March 7, 2025
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