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The emerging landscape of single-molecule protein sequencing technologies

Published

Author(s)

Zvi Kelman, John Marino

Abstract

Single-cell profiling methods have had a profound impact on the understanding of cellular heterogeneity. While genomes and transcriptomes can be explored at the single-cell level, single-cell profiling of proteomes is not yet established. Here we describe new single-molecule protein sequencing and identification technologies alongside innovations in mass spectrometry that will eventually enable broad sequence coverage in single-cell profiling. These technologies will in turn facilitate biological discovery and open new avenues for ultrasensitive disease diagnostics.
Citation
Nature Methods

Keywords

Protein sequencing, proteom

Citation

Kelman, Z. and Marino, J. (2023), The emerging landscape of single-molecule protein sequencing technologies, Nature Methods (Accessed February 26, 2024)
Created April 11, 2023