My research expertise is in the characterization of (bio)molecules at surfaces (planar and nanomaterial) with the goal being understanding, controlling and/or improving molecular adhesion and presentation for varied applications. My most recent research was investigating affinity methods for glycan analysis in the context of biomanufacturing of protein drug products. The glycosylation, or sugar decoration patterns, in a protein product can affect the safety and efficacy of that product and requires careful monitoring at various stages in the product development and manufacturing process. Current projects use lectins, or carbohydrate binding proteins, in the development of rapid and robust glycoassays, with an emphasis on the understanding of the binding between lectins and carbohydrates (free or attached to a protein) when one or both is tethered to a sensing element.
Currently, I am serving as the Science Advisor for the Biomolecular Measurement Division at NIST.