My research expertise is in the characterization of (bio)molecules at surfaces (planar and nanomaterial) with the goal being understanding, controlling and/or improving molecular adhesion and presentation for varied applications. My most recent research was investigating affinity methods for glycan analysis in the context of biomanufacturing of protein drug products. The glycosylation, or sugar decoration patterns, in a protein product can affect the safety and efficacy of that product and requires careful monitoring at various stages in the product development and manufacturing process. Lectins, or carbohydrate binding proteins, were used in the development of rapid and robust glycoassays, with an emphasis on the understanding of the binding between lectins and carbohydrates (free or attached to a protein) when one or both is tethered to a sensing element.
Currently, I am Deputy Division Chief of the Biomolecular Measurement Division (BMD) at NIST. In addition to working for BMD at NIST, I am also serving the larger scientific community in the following capacities:
U.S. Department of Commerce Silver Medal Award for developing gold nanoparticle reference materials for biomedical applications and environmental, health, and safety risk assessment, 2008
NIST Material Measurement Laboratory Accolade for exemplary leadership, professionalism, and innovation during her three-year coordination of the impactful SURF program, 2018