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Application of X-ray photoelectron spectroscopic analysis to protein adsorption on materials relevant to biomanufacturing.

Published

Author(s)

Rebecca A. A. Zangmeister

Abstract

The use of X-ray photoelectron spectroscopy (XPS) for the analysis of protein adsorption on materials relevant to biomanufacturing of protein drug products is explored. Details of the methods used to obtain three pieces of information about protein adsorption on materials relevant to bioprocessing will be described: I) confirmation of protein adsorption, II) an estimate of how much protein is adsorbed and III) the conformational state (native or denatured) of the protein on the surface.
Citation
Journal of Pharmaceutical Sciences
Volume
101
Issue
4

Keywords

biomanufacturing, heteroatom labeling, protein, surface adsorption, therapeutic, X-ray photoelectron spectroscopy (XPS)

Citation

Zangmeister, R. (2012), Application of X-ray photoelectron spectroscopic analysis to protein adsorption on materials relevant to biomanufacturing., Journal of Pharmaceutical Sciences, [online], https://doi.org/10.1002/jps.23023 (Accessed June 18, 2024)

Issues

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Created January 5, 2012, Updated September 11, 2023