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Edward Kwee (Fed)

Biologist

Research Interests

  • Measurement of proliferative and cytotoxic heterogeneity in chimeric antigen receptor T (CAR-T) cells using single cell, live cell imaging and machine learning models. 
  • Quantitative assessment viral vector infectivity (lentivirus, pseudovirus) dynamics and heterogeneity using cell based assays and live cell imaging.
  • Quantitative phase imaging (QPI) reference materials to enable reproducible and comparable QPI measurements between different experiments and laboratories

 

 

Quantitative phase image of induced pluripotent stem cells and reference beads
Quantitative Phase Imaging. Left) Induced Pluripotent Stem Cell Colony: Live QPI image of induced pluripotent stem cell colony. Right) QPI image of candidate reference beads. Image intensity is proportional to optical pathlength difference in nanometers.

 

Past Publications

  1. Kwee, E. et al. “Quantifying Proliferative and Surface Marker Heterogeneity in Colony Founding Connective Tissue Progenitors and Their Progeny Using Time-Lapse Microscopy” Journal of Tissue Engineering and Regenerative Medicine. (2019) 13(2):203-216.
  2. Piuzzi, NS, Mantripragada, VP, Kwee, E, et al. “Bone Marrow-Derived Cellular Therapies in Orthopaedics: Part II: Recommendations for Reporting the Quality of Bone Marrow-Derived Cell Populations.” JBJS Reviews. (2018);6(11):e5.
  3. Kwee, E, et al. "Integrated Colony Imaging, Analysis, and Selection Device for Regenerative Medicine." SLAS Technology. 22.2 (2017): 217-223.
  4. Powell, K., Kwee, E., et al.. "Variability in subjective review of umbilical cord blood colony forming unit assay." Cytometry Part B: Clinical Cytometry, 2016. 90(6): 517-524.
  5. Kwee, E., Powell, K., and Muschler, G. Characterization of connective tissue progenitors through phase contrast and multicolor fluorescence time-lapse microscopy ", Proc. SPIE 9328, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XIII, 93280O, 2015.

Awards

Sigma Xi Most Outstanding Biology Poster at NIST Post-doc Poster Presentation, 2018

BioImage Informatics Travel Award, 2017

National Research Council Postdoctoral Research Associateship, 2016

AAAS/Science Program for Excellence in Science, 2015

Alpha Epsilon: Honor Society of Biological Engineering, 2010

Cornell Engineering Co-op of the Year, 2009

Publications

Created December 10, 2018, Updated September 2, 2021