Edward Kwee is a NIST-NRC Postdoctoral Research Associate working with his advisor, John Elliott, in the Cell Systems Science Group. He completed his PhD in Biomedical Engineering from Case Western Reserve University in 2016. His dissertation research was performed in the lab of Dr. George Muschler at the Cleveland Clinic where Edward worked on characterizing bone derived stem and progenitor cell heterogeneity using time lapse imaging, image analysis, and cell picking. The goal of his current work is to contribute to traceable, non-invasive metrology in cell therapy biomanufacturing.
Induced pluripotent stem cells (iPSCs) are reprogrammed cells with varying biological potential for use in cell therapy products. There is a need for objective, non-invasive live cell methods to identify differences in pluripotency and aid in the manufacturing of desired iPSCs. Edward’s research focuses on the use of quantitative phase imaging (QPI) as a traceable, quantitative measure of iPSC potency. QPI provides quantitative measurements of the change in the phase of light through cells and their surroundings. This enables measurement of cell thickness, volume, and mass. Edward is also working on the development of traceable QPI reference materials to enable reproducible and comparable QPI measurements between different experiments and laboratories.
National Research Council Postdoctoral Research Associateship, 2016
AAAS/Science Program for Excellence in Science, 2015
Alpha Epsilon: Honor Society of Biological Engineering, 2010
Cornell Engineering Co-op of the Year, 2009