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Dean C Ripple (Fed)

Dean Ripple joined NIST as a post-doctorate in 1991. After a successful career at NIST supporting improved methods and standards in thermometry, in 2010 they became Leader of the Bioprocess Measurements Group, which develops standards and sensing technologies in support of biotherapeutic manufacturing and health care. Dean has presented workshops on measurement issues to many industrial groups, ranging from petroleum producers to vaccination program coordinators. They have authored over 80 scientific papers and documentary standards on a variety of metrology topics. Dean is an active member of a USP Expert Panel and the ASTM committee on the Manufacture of Pharmaceutical Products.

His present research focuses on the development of new standards and measurement methods for particles in biopharmaceuticals. Active projects include: 

  • particle size and count standards, from 10s of nanometers to the visible
  • next-generation particle characterization methods
  • improved methods for reliable number concentration measurements below 1 µm


  • 2021, Bronze Medal from the National Institute of Standards and Technology
  • 2011, Safety Award from the National Institute of Standards and Technology
  • 2009, Certificate of Achievement from ASME
  • 2006, Silver Medal from the U.S. Department of Commerce
  • 2004, Award of Merit from ASTM
  • 2004, Bronze Medal from the National Institute of Standards and Technology

Selected Publications

Standards for the Optical Detection of Protein Particulates

Dean C. Ripple, Michael J. Carrier, Joshua R. Wayment
Particulates in protein therapeutics, composed of agglomerated protein monomers, may cause an immunogenic response in patients. Consequently, industry and the


Created September 10, 2019, Updated December 8, 2022