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David M. Bunk

David's research at NIST has focused on improving quantitative measurement of proteins, employing both chromatography and mass spectrometry. For the past 15 years, his efforts have been directed at standardizing clinical diagnostic measurement of proteins through the development of certified reference materials and reference measurement procedures. He has collaborated on several standardization projects with the American Association for Clinical Chemistry and the International Federation of Clinical Chemistry and served on committees and working groups for the Clinical and Laboratory Standards Institute. His recent standardization projects include the development of reference materials and measurement procedures for the clinical measurements of cardiac troponin I, C-reactive protein, urine albumin, and prostate specific antigen. Additionally, he has worked in the past three years with the National Cancer Institute to improve measurement quality in clinical proteomic investigations, supporting the Clinical Proteomic Technology Assessment for Cancer (CPTAC) interlaboratory programs.

Membership and Professional Activities:

  • Clinical Laboratory Standards Institute
    - Member, Clinical Chemistry and Toxicology Area Committee – 2004 to present
    - Advisor, Subcommittee on Characterization and Qualification of Commutable Reference Materials for Laboratory Medicine – 2005 to 2007
  • American Association for Clinical Chemistry
    - Advisor, Troponin I Standardization Subcommittee – 2004 to 2005
  • Joint Committee for Traceability in Laboratory Medicine
    - Protein Review Team Chair – 2006 to present
  • United States Pharmacopeia Advisory Panel on Peptide Mapping – 2008 to present
  • International Federation for Clinical Chemistry
    - Advisor, Scientific Division – 2007 to present
    - Member, Working Group for the Standard of Cardiac Troponin -  2008 to present
    - Member, Working Group on Standardization of Albumin in Urine – 2008 to present

Publications

Multiplexed LC-MS/MS Assay for Urine Albumin

Author(s)
Ashley B. Green, David M. Bunk, Karen W. Phinney
Targeted Multiplexed Assay for Urinary Albumin Quantification Ashley Beasley-Green, Nijah M. Burris, David Bunk, Karen Phinney Biomolecular Measurement Division

A reference system for urinary albumin: current status

Author(s)
David M. Bunk, Karen W. Phinney, John C. Lieske, Olga Bondar, W. Greg Miller, Lorin M. Bachmann, Andrew S. Narva, Yoshihisa Itoh, Schimmel Heinz
Background: Increased urinary excretion of albumin reflects kidney damage and is a recognized risk factor for progression of renal and cardiovascular disease
Created October 9, 2019