David's research at NIST has focused on improving quantitative measurement of proteins, employing both chromatography and mass spectrometry. For the past 15 years, his efforts have been directed at standardizing clinical diagnostic measurement of proteins through the development of certified reference materials and reference measurement procedures. He has collaborated on several standardization projects with the American Association for Clinical Chemistry and the International Federation of Clinical Chemistry and served on committees and working groups for the Clinical and Laboratory Standards Institute. His recent standardization projects include the development of reference materials and measurement procedures for the clinical measurements of cardiac troponin I, C-reactive protein, urine albumin, and prostate specific antigen. Additionally, he has worked in the past three years with the National Cancer Institute to improve measurement quality in clinical proteomic investigations, supporting the Clinical Proteomic Technology Assessment for Cancer (CPTAC) interlaboratory programs.
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