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Search Patents by Samuel Schaffter

Patents listed here reflect only technologies patented from FY 2018-present. To view all of NIST's patented technologies, visit the NIST pages on the Federal Laboratory Consortium website.

Displaying 1 - 2 of 2
(a) Without an aptamer’s protein ligand, dARTs are transcribed to produce RNA outputs (left), while protein binding represses transcription (middle). The input and output domains are decoupled (right), enabling modular design of dARTs by swapping out the aptamer domain or customizing the output sequences. (b) dARTs serve as the protein sensing layer (left) whose outputs can be coupled with downstream circuits (middle). RNA outputs are measured via fluorescence (right).

Aptamer Regulated Transcription For In-Vitro Sensing And Transduction

NIST Inventors
Samuel Schaffter
It relates to nucleic acid transcription templates, systems, and methods for detection and measurement of molecules and biomolecules (e.g., biomarkers). Particularly, systems and methods utilize a transcription template with an aptamer domain configured to bind a molecule of interest to regulate
Depiction of co-transcriptional RNA strand displacement (ctRSD) design.

CTRSD Gate And Performing Co-Transcriptional Encoding

NIST Inventors
Samuel Schaffter
Scalable and programmable co-transcriptional RNA strand displacement (ctRSD) circuits. In ctRSD, circuit components isothermally self-assemble and execute programmed computations in a single transcription reaction. This is achieved through two new innovations: 1) the use of the HDV self-cleaving
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