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Search Patents by Paul Patrone

Patents listed here reflect only technologies patented from FY 2018-present. To view all of NIST's patented technologies, visit the NIST pages on the Federal Laboratory Consortium website.

Displaying 1 - 6 of 6
The optofluidic flowmeter determines flow rate by measuring the amount of photobleaching in a dye such as fluorescein.

Optical Flow Meter

NIST Inventors
Anthony J. Kearsley , Paul Patrone and Gregory A Cooksey
NIST scientists have developed an optical flow meter that can continuously measure flow in the nanoliter per minute range. Over the instrument’s dynamic range, the relative uncertainty in flow rate remains constant and can be controlled to within 5% or better. No existing technology can

Multiplexed Amplitude Modulation Fluorometry

NIST Inventors
Anthony J. Kearsley , Gregory A Cooksey and Paul Patrone
Improving accuracy of cytometers is challenging because optical configuration, flow control methods, and calibration issues make it difficult to characterize geometric factors associated with signal collection. State-of-the-art tools only collect a small solid angle of emitted light, so that minor
Serial cytometry involves making repeated measurements of single objects as they pass through multiple interrogation regions in a microfluidic channel. Integrated optical waveguides deliver and collect light from objects. Matching and analysis of signals from individual cells, for example, enable uncertainty estimates on the biomarker content of each cell, which enables better comparison and classification of cells and mixture of cells.

Serial Cytometry

NIST Inventors
Gregory A Cooksey , Paul Patrone and Anthony J. Kearsley
NIST scientists have developed a microfluidic flow cytometer that is capable of robust and repeated measurements that provide first-of-their-kind uncertainty estimates, which support better comparability and classification of cytometry data. The device measures single objects in flow several times

System And Method For Data Analysis In Quantitative PCR Measurements

NIST Inventors
Anthony J. Kearsley , Paul Patrone , Erica Romsos and Peter M. Vallone
In quantitative polymerase chain-reaction (qPCR) measurements, accurately subtracting background signals, quantifying the amount of DNA, and ensuring fidelity of data analysis and diagnostic tests is challenging. Such problems are especially acute for emerging / novel diseases that lack thoroughly
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