Green, A.
, Camara, J.
and Heckert, N.
(2025),
Certification of Standard Reference Material® 3666: Albumin and Creatinine in Frozen Human Urine - INCLUDES UPDATES AS OF 07-02-2025, Special Publication (NIST SP), National Institute of Standards and Technology, Gaithersburg, MD, [online], https://doi.org/10.6028/NIST.SP.260-238-upd2 (Accessed September 8, 2026)
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
Certification of Standard Reference Material® 3666: Albumin and Creatinine in Frozen Human Urine - INCLUDES UPDATES AS OF 07-02-2025
Published
Author(s)
, ,
Abstract
The National Institute of Standards and Technology (NIST) Standard Reference Material® (SRM®) 3666 Albumin and Creatinine in Frozen Human Urine is a secondary measurement standard for albumin and creatinine in human urine. The material is intended for use in a calibration hierarchy, in the validation of measurement procedures, or as quality control material for the determination of albumin, creatinine, or the albumin-to-creatinine ratio (ACR) in human urine. A unit of SRM 3666 consists of four (4) vials of frozen pooled human urine with four (4) different levels (Level I to Level IV) of endogenous albumin determined using the NIST candidate reference measurement procedure (RMP) for albumin in urine; and creatinine determined using a modification of the NIST RMP for creatinine in serum. The certified values and associated uncertainties for albumin and creatinine were used to calculate the ACR for each level (Level I to Level IV). This publication documents the production, measurement processes, results, and statistical evaluations involved in the production and certification of SRM 3666.Citation
Special Publication (NIST SP) - 260-238-upd2
Report Number
260-238-upd2
NIST Pub Series
Pub Type
NIST Pubs
Download Paper
Keywords
Albumin, Albumin-to-Creatinine Ratio (ACR), Creatinine, Human Urine, Reference Measurement Procedure (RMP), Standard Reference Material (SRM)
Citation
Issues
If you have any questions about this publication or are having problems accessing it, please contact [email protected].
Created July 2, 2025, Updated August 28, 2026