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In Vitro and in Vivo Characteristics of Fluorapatite-forming Calcium Phosphate Cements



Shozo Takagi, Stanislav A. Frukhtbeyn, Laurence C. Chow, Akiyoshi Sugawara, Kenji Fujikawa, Kidehiro Ogata, Makoto Hayashi, Bunnai Ogiso


This study reports for the first time in vitro and in vivo properties of fluorapatite (FA)-forming calcium phosphate cements (CPCs). The experimental cements contained from (0 to 3.3) mass % of F, corresponding to presence of FA at levels of approximately (0 to 87) mass %. The crystallinity of the apatitic cement product increased greatly with the FA content. When implanted subcutaneously in rats, the in vivo resorption rate decreased significantly with increasing FA content. The cement with the highest FA content was found to be not resorbed in soft tissue, making it the first known biocompatible and bioinert CPC. These bioinert CPCs might be useful for applications where slow or no resorption of the implant is required to achieve desired clinical outcome.
Journal of Research (NIST JRES) -


fluorapatite-forming calcium phosphate cement, high crystallinity, biocompatible, animal study, non-resorbable.


Takagi, S. , Frukhtbeyn, S. , Chow, L. , Sugawara, A. , Fujikawa, K. , Ogata, K. , Hayashi, M. and Ogiso, B. (2010), In Vitro and in Vivo Characteristics of Fluorapatite-forming Calcium Phosphate Cements, Journal of Research (NIST JRES), National Institute of Standards and Technology, Gaithersburg, MD, [online], (Accessed April 23, 2024)
Created August 1, 2010, Updated November 14, 2018