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A Versatile Gradient Substrate for Biofunctionalization



Nathan D. Gallant, Matthew Becker, Eric J. Amis


NIST has developed numerous platforms for characterizing the physical properties of sample libraries with orthogonal gradients using combinatorial methodologies. Extension of these methods includes the characterization of surfaces possessing well-defined gradients of immobilized biomolecules designed to control cell adhesion and direct cell function. Our approach to the fabrication of bioactive surface gradients has been to develop and characterize a functional gradient substrate to which various species can be attached. The syntheses, characterization and preliminary biological assessment of these versatile bioactive substrates, and in particular films possessing gradients of RGD peptides, will be described.
Proceedings Title
New Jersey Symposium on Biomaterials Science | 8th | | The New Jersey Center for Biomaterials
Conference Dates
November 8-10, 2006
Conference Title
New Jersey Symposium on Biomaterials Science


biomaterials, cell adhesion, combinatorial, gradient, peptide, RGD


Gallant, N. , Becker, M. and Amis, E. (2006), A Versatile Gradient Substrate for Biofunctionalization, New Jersey Symposium on Biomaterials Science | 8th | | The New Jersey Center for Biomaterials, [online], (Accessed July 22, 2024)


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Created November 5, 2006, Updated February 17, 2017