A Versatile Gradient Substrate for Biofunctionalization
Nathan D. Gallant, Matthew Becker, Eric J. Amis
NIST has developed numerous platforms for characterizing the physical properties of sample libraries with orthogonal gradients using combinatorial methodologies. Extension of these methods includes the characterization of surfaces possessing well-defined gradients of immobilized biomolecules designed to control cell adhesion and direct cell function. Our approach to the fabrication of bioactive surface gradients has been to develop and characterize a functional gradient substrate to which various species can be attached. The syntheses, characterization and preliminary biological assessment of these versatile bioactive substrates, and in particular films possessing gradients of RGD peptides, will be described.
New Jersey Symposium on Biomaterials Science | 8th | | The New Jersey Center for Biomaterials
, Becker, M.
and Amis, E.
A Versatile Gradient Substrate for Biofunctionalization, New Jersey Symposium on Biomaterials Science | 8th | | The New Jersey Center for Biomaterials, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=852632
(Accessed February 23, 2024)