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Vapor Pressure Measurements on Linalool Using a Rapid and Inexpensive Method Suitable for Cannabis-Associated Terpenes

Published

Author(s)

Cheryle Beuning, Tara Lovestead, Marcia L. Huber, Jason A. Widegren

Abstract

Vapor pressure (psat) data are needed to assess the potential use of terpenes as breath markers of recent cannabis use. Herein, a recently introduced gas-saturation method for psat measurements, known as dynamic vapor microextraction (DVME), was used to measure psat for the terpene (±)-3,7-dimethylocta-1,6-dien-3-ol, commonly known as linalool. The DVME apparatus utilizes inexpensive and commercially available components, a low internal volume, and helium carrier gas to minimize nonideal mixture behavior. In the temperature range from 314 K to 354 K, DVME-based measurements of the psat of linalool ranged from 81 Pa to 1250 Pa. With a measurement period of 30 min, the combined standard uncertainty of these measurements ranged from 0.0358∙psat to 0.0584∙psat, depending on temperature. The DVME-based measurements agree with a Wagner correlation of available literature data. We demonstrate that DVME produces accurate results for values of psat that are 200 times higher than in the DVME validation study with n-eicosane (C20H42). The oxidative stability of linalool was improved by the addition of 0.2 mass % of the antioxidant tert-butylhydroquinone.
Citation
Journal of Chemical and Engineering Data
Volume
68
Issue
12

Keywords

Vapor pressure measurement, semivolatile organic compounds, SVOCs, gas saturation method, dynamic vapor microextraction, TBHQ antioxidant, linalool, monoterpene, uncertainty analysis

Citation

Beuning, C. , Lovestead, T. , Huber, M. and Widegren, J. (2023), Vapor Pressure Measurements on Linalool Using a Rapid and Inexpensive Method Suitable for Cannabis-Associated Terpenes, Journal of Chemical and Engineering Data, [online], https://doi.org/10.1021/acs.jced.3c00360, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=935152 (Accessed March 1, 2024)
Created October 7, 2023, Updated January 3, 2024