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Urine Proteomics in the Era of Mass Spectrometry



Ashley B. Green


With the technological advances of mass spectrometry (MS)-based platforms, clinical proteomics is one of the most rapidly growing areas in biomedical research. Urine proteomics has become a popular sub-discipline of clinical proteomics because it is an ideal source for the discovery of noninvasive disease biomarkers. The urine proteome offers a comprehensive view of the local and systemic physiology since the proteome is primarily composed of proteins/peptides from the kidneys and plasma. The emergence of MS-based proteomic platforms as prominent bioanalytical tools in clinical applications has enhanced the identification of protein-based urinary biomarkers. This review highlights the characteristics of urine that make it an attractive biofluid for biomarker discovery and the impact of MS-based technologies on the clinical assessment of urinary protein biomarkers.
International Neurourology Journal


Green, A. (2016), Urine Proteomics in the Era of Mass Spectrometry, International Neurourology Journal (Accessed May 24, 2024)


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Created November 22, 2016, Updated March 21, 2017