An untargeted approach to determine the authenticity of Ginkgo biloba L. plant materials and dried leaf extracts by liquid chromatography-mass spectrometry (LC-HRMS) and chemometrics.
Meryl B. Cruz, Benjamin Place, Laura J. Wood, Aaron A. Urbas, Werickson Rocha, Andrzej Wasik
The lack of stringent regulations regarding raw materials for herbal supplements used for medicinal purposes has been a constant challenge in the industry. Ginkgo biloba L. leaf extracts attract consumers because of the supposed positive effect on mental performance and memory. Supplements are produced using dried leaf materials and standardized leaf extracts such as EGb 761. Adulteration of Ginkgo biloba L. plants and extracts are becoming more and more common practice due to economically driven motivation from increasing demand in the market and the high cost of raw materials and production. Reinforcement in quality control (QC) to avoid adulterations is necessary to ensure the efficacy of the supplements. In this study, liquid chromatography coupled with high resolution mass spectrometry (LC-HRMS) was used with principal component analysis (PCA) as an unsupervised exploratory method to analyze, identify, and evaluate the adulterated Ginkgo biloba L. plant materials and dried leaf extracts through trends and identification of compounds.
, Place, B.
, Wood, L.
, Urbas, A.
, Rocha, W.
and Wasik, A.
An untargeted approach to determine the authenticity of Ginkgo biloba L. plant materials and dried leaf extracts by liquid chromatography-mass spectrometry (LC-HRMS) and chemometrics., Analytical and Bioanalytical Chemistry, [online], https://doi.org/10.1007/s00216-020-02830-2, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=929441
(Accessed June 29, 2022)