Towards quality assurance and quality control in untargeted metabolomics studies

Published

January 3, 2019

Author(s)

Richard Beger, Warwick B. Dunn, Abbas Bandukwala, Bianca Bethan, David Broadhurst, Clary B. Clish, Surendra Dasari, Leslie Derr, Annie Evans, Steve Fischer, Thomas Flynn, Thomas Hartung, David Herrington, Richard Higashi, Ping-Ching Hsu, Christina Jones, Maureen Kachman, Helen Karuso, Gary Kruppa, Katrice Lippa, Padma Maruvada, Jonathan D. Mosley, Ionna Ntai, Clair O?Donovan, Mary Playdon, Daniel Raftery, Daniel Shaughnessy, Amanda Souza, Timothy Spaeder, Barbara Spalholz, Mukesh Verma, Tilman Walk, Ian Wilson, Daniel Bearden, Krista Zanetti

Abstract

We describe here the agreed upon first development steps and priority objectives of a community engagement effort to address current challenges in quality assurance (QA) and quality control (QC) in untargeted metabolomic studies. This has included (1) a QA and QC questionnaire responded to by the metabolomics community in 2015 which recommended education of the metabolomics community, development of appropriate standard reference materials and providing incentives for laboratories to apply QA and QC; (2) a 2-day ‘Think Tank on Quality Assurance and Quality Control for Untargeted Metabolomic Studies' held at the National Cancer Institute's Shady Grove Campus and (3) establishment of the Metabolomics Quality Assurance and Quality Control Consortium (mQACC) to drive forward developments in a coordinated manner.

Citation

Nature - Scientific Reports

Pub Type

Journals

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Citation

Beger, R. , Dunn, W. , Bandukwala, A. , Bethan, B. , Broadhurst, D. , Clish, C. , Dasari, S. , Derr, L. , Evans, A. , Fischer, S. , Flynn, T. , Hartung, T. , Herrington, D. , Higashi, R. , Hsu, P. , Jones, C. , Kachman, M. , Karuso, H. , Kruppa, G. , Lippa, K. , Maruvada, P. , Mosley, J. , Ntai, I. , O?Donovan, C. , Playdon, M. , Raftery, D. , Shaughnessy, D. , Souza, A. , Spaeder, T. , Spalholz, B. , Verma, M. , Walk, T. , Wilson, I. , Bearden, D. and Zanetti, K. (2019), Towards quality assurance and quality control in untargeted metabolomics studies, Nature - Scientific Reports, [online], https://doi.org/10.1007/s11306-018-1460-7 (Accessed April 26, 2024)