Time of Flight Secondary Ion Mass Spectrometry (TOF-SIMS) for High-Throughput Characterization of Bio-Surfaces

Published

January 1, 2003

Author(s)

S V. Roberson, A Sehgal, Albert J. Fahey, Alamgir Karim

Abstract

A graded oxidation process, involving UV-ozone (UVO) treatment, was used to create a poly(epsilon-caprolactone) (PCL) surface with a systematic variation in surface chemistry. Time-of-fight secondary ion mass spectrometry (TOF-SIMS) has proved useful in characterizing the chemical composition of these surfaces and in monitoring the oxidation process. The TOF-SIMS data correlates with contact angle data and the results of the binding studies performed with mouse calvarial cells. UVO treatment resulted in a PCL surface with improved wettability and cellular adhesion.

Citation

Applied Surface Science

Volume

203

Pub Type

Journals

Keywords

osteoblast cells, poly (epsilon-caprolactone), polymers, POLYMERS, SILICONE-OXIDE, surface energy gradient, TOF-SIMS, UV-ozone treatment

Citation

Roberson, S. , Sehgal, A. , Fahey, A. and Karim, A. (2003), Time of Flight Secondary Ion Mass Spectrometry (TOF-SIMS) for High-Throughput Characterization of Bio-Surfaces, Applied Surface Science (Accessed October 17, 2025)