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Three-Dimensionally Ordered Macroporous Sol-Gel Bioactive Glass (3DOM-BG) Particles and Their In Vitro Biocompatibility

Published

Author(s)

K Zhang, N Washburn, Carl G. Simon Jr.

Abstract

Sol-gel bioactive materials are one of the new generation biomaterials that are both bioactive and bioresorbable. The three-dimensionally ordered macroporous (pore size 200-1000 nm) sol-gel bioactive glasses (3DOM-BGs) generate many interesting properties. For example, 3DOM-BGs can quickly and completely convert to calcium-deficient, bone-like apatite in a simulated body fluid (SBF). In this study, 3DOM-BG particles were prepared and characterized. Their in vitro MC3T3-E1 cellular compatibility was tested by the following techniques: (1) Wst-1 assay for cell viability after culture in extracts of 3DOM-BG particles; (2) phase contrast microscopy for cell morphology after culturing in the presence of 3DOM-BG particles; and (3) fluorescence microscopy for imaging cells cultured directly on 3DOM-BG particles. Results demonstrated that 3DOM-BG particles are not cytotoxic and are biocompatible with MC3T3-E1 osteoblasts.
Citation
Biomaterials
Volume
26

Keywords

apatite, bioactive, biocompatibility, biomaterial

Citation

Zhang, K. , Washburn, N. and Simon, C. (2005), Three-Dimensionally Ordered Macroporous Sol-Gel Bioactive Glass (3DOM-BG) Particles and Their In Vitro Biocompatibility, Biomaterials, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=852406 (Accessed June 13, 2024)

Issues

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Created April 25, 2005, Updated February 17, 2017