Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Thermochemistry of Adenosine



J A. Boerio-Goates, M R. Francis, Robert N. Goldberg, M A. Ribeiro da Silva, M D. Ribeiro da Silva, Yadu D. Tewari


The thermochemistry of adenosine(cr) was studied by a variety of methods: the standard (pressure p = 0.1 MPa) molar enthalpy of combustion in oxygen at T = 298.15 K was measured by means of combustion calorimetry and was found to be Δ}cH m = -(5139.4 3.3) kJ × molu-1^; the standard molar heat capacity C p,m was determined by means of adiabatic calorimetry for the range 11 less then or equal to} T/K less then or equal to} 328 C p,m = (290.10 0.58) J × K-1 × mol-1 at T = 298.15 K}; and the saturation molality in water was measured by means of high-performance liquid chromatography and was found to be m(sat) = (1.849 0.015) × 10-2 mol × kg-1 at T = 298.15 K. Derived quantities at T = 298.15 K for adenosine(cr) are the standard molar enthalpy of formation Δ}fH m = -(653.6 3.6) kJ × mol-1, the third law standard molar entropy S m = (289.57 0.6) J × K-1 × mol-1, and the standard molar Gibbs free energy of formation Δ}fG m = -(204.4 3.6) kJ × mol-1. The function Phi m = Δ}T0S m - Δ}T^0H m/T for adenosine(s) was tabulated for 5 less then or equal to} T/K less then or equal to} 320. A thermochemical cycle was used to calculate Δ}fG m = -(194.5 3.6) kJ × mol-1, Δ}fH m = -(621.3 ± 3.6) kJ × mol-1, and S m = (364.6 0.7) J × K-1 × mol-1 for adenosine(aq) at T = 298.15 K. These values in turn were used to calculate standard molar formation properties at T = 298.15 K and ionic strength I = 0 for the adenosine 5'-monophosphate (AMP), adenosine 5'-diphosphate (ADP), and adenosine 5'-triphosphate (ATP) series of aqueous species. Standard molar transformed formation properties for the aqueous biochemical reactants adenosine, AMP, ADP, and ATP have also been calculated at T = 298.15 K, pH = 7.0, pMg = 3.0, and I = 0.25 mol × kg-1.
Journal of Chemical Thermodynamics
No. 8


adenosine, adenosine 5'-triphosphate, ATP, enthalpy of combustion, entropy, heat capacity, saturation molality, std transformed formation properties


Boerio-Goates, J. , Francis, M. , Goldberg, R. , Ribeiro da Silva, M. , Ribeiro da Silva, M. and Tewari, Y. (2001), Thermochemistry of Adenosine, Journal of Chemical Thermodynamics (Accessed June 16, 2024)


If you have any questions about this publication or are having problems accessing it, please contact

Created July 31, 2001, Updated October 12, 2021