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Thermochemistry of Adenosine

Published

Author(s)

J A. Boerio-Goates, M R. Francis, Robert N. Goldberg, M A. Ribeiro da Silva, M D. Ribeiro da Silva, Yadu D. Tewari

Abstract

The thermochemistry of adenosine(cr) was studied by a variety of methods: the standard (pressure p = 0.1 MPa) molar enthalpy of combustion in oxygen at T = 298.15 K was measured by means of combustion calorimetry and was found to be Δ}cH m = -(5139.4 3.3) kJ × molu-1^; the standard molar heat capacity C p,m was determined by means of adiabatic calorimetry for the range 11 less then or equal to} T/K less then or equal to} 328 C p,m = (290.10 0.58) J × K-1 × mol-1 at T = 298.15 K}; and the saturation molality in water was measured by means of high-performance liquid chromatography and was found to be m(sat) = (1.849 0.015) × 10-2 mol × kg-1 at T = 298.15 K. Derived quantities at T = 298.15 K for adenosine(cr) are the standard molar enthalpy of formation Δ}fH m = -(653.6 3.6) kJ × mol-1, the third law standard molar entropy S m = (289.57 0.6) J × K-1 × mol-1, and the standard molar Gibbs free energy of formation Δ}fG m = -(204.4 3.6) kJ × mol-1. The function Phi m = Δ}T0S m - Δ}T^0H m/T for adenosine(s) was tabulated for 5 less then or equal to} T/K less then or equal to} 320. A thermochemical cycle was used to calculate Δ}fG m = -(194.5 3.6) kJ × mol-1, Δ}fH m = -(621.3 ± 3.6) kJ × mol-1, and S m = (364.6 0.7) J × K-1 × mol-1 for adenosine(aq) at T = 298.15 K. These values in turn were used to calculate standard molar formation properties at T = 298.15 K and ionic strength I = 0 for the adenosine 5'-monophosphate (AMP), adenosine 5'-diphosphate (ADP), and adenosine 5'-triphosphate (ATP) series of aqueous species. Standard molar transformed formation properties for the aqueous biochemical reactants adenosine, AMP, ADP, and ATP have also been calculated at T = 298.15 K, pH = 7.0, pMg = 3.0, and I = 0.25 mol × kg-1.
Citation
Journal of Chemical Thermodynamics
Volume
33
Issue
No. 8

Keywords

adenosine, adenosine 5'-triphosphate, ATP, enthalpy of combustion, entropy, heat capacity, saturation molality, std transformed formation properties

Citation

Boerio-Goates, J. , Francis, M. , Goldberg, R. , Ribeiro da Silva, M. , Ribeiro da Silva, M. and Tewari, Y. (2001), Thermochemistry of Adenosine, Journal of Chemical Thermodynamics (Accessed June 16, 2024)

Issues

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Created July 31, 2001, Updated October 12, 2021