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Temperature-Controlled Electrochemical Microwell Platform for Studying Biomolecular Interactions



Stephen Semancik, Zuliang Shen, Herman O. Sintim


We designed and fabricated, on a 4-inch wafer, prototype devices for proof-of-concept studies on biomolecular interactions. The platform includes eight probe sites, each consisting of one 200nm thick platinum (Pt) heater, one 200nm gold (Au) and two 200nm Pt electrodes, as well as a 20uL polydimethylsiloxane (PDMS) well for electrochemical probing of samples. The Pt heaters have the ability to increase sample temperatures up to 120ºC. The device can perform electrochemical binding based measurements that detect changes in methylene blue (MB)-labeled DNA attached on the Au electrodes.
Proceedings Title
Conference Dates
November 4-6, 2013
Conference Location
Baltimore, MD


biomolecular interactions, mems, heater, electrochemical, melting, DNA


Semancik, S. , Shen, Z. and Sintim, H. (2013), Temperature-Controlled Electrochemical Microwell Platform for Studying Biomolecular Interactions, IEEE SENSORS 2013, Baltimore, MD, [online], (Accessed April 24, 2024)
Created November 3, 2013, Updated November 10, 2018