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Marija Dubackic, Veronica Lattanzi, Yun Liu, Michael Haertlein, Juliette Devos, Emma Sparr, Sara Linse, Ulf Olsson
Abstract
We have investigated the interactions between α-Synuclein (aSyn) and small unilamellar vesicles composed of a mixture of zwitterionic POPC and anionic POPS lipids. aSyn monomers spontaneously adsorb onto the anionic lipid vesicles where they adopt an α-helix secondary structure. The amount of formed α-helices depends on the fraction of anionic lipid in the mixed lipid membrane. Under the conditions where aSyn fibril formation is not occurring, the vesicles with adsorbed monomers are undeformed. However, after fibrils have been formed, here triggered by the addition of a small concentration of pre-formed fibrils (seeds), the average vesicle size has increased by approximately a factor of two, indicating that a few fusion events have been taking place during the aggregation process.
Dubackic, M.
, Lattanzi, V.
, Liu, Y.
, Haertlein, M.
, Devos, J.
, Sparr, E.
, Linse, S.
and Olsson, U.
(2025),
α-Synuclein interaction with POPC/POPS vesicles, Soft Matter, [online], https://doi.org/10.1039/d4sm01036a, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=958401
(Accessed October 1, 2025)