Structure-Property Relationships for Biodegradability in Copolyesters

Published

June 18, 2026

Author(s)

Katharina Fransen, Julia Casey, Gabrielle Godbille-Cardona, Natalie Mamrol, Jiale Shi, Alex Zappi, Jignesh Mahajan, Jiarui Lu, Debra Audus, Bradley Olsen

Abstract

With growing concerns about increasing plastic pollution, interest in biodegradable polymers, particularly polyesters, continues to grow. Copolymerization is an important molecular handle to tune properties to achieve material performance and biodegradation simultaneously. To better understand the structure–property relationships that govern biodegradability, a 300-member copolymer library was synthesized and tested using a high-throughput clear-zone biodegradation assay; testing shows over 80% of the copolymer library is biodegradable even though only 50% of the homopolymers from which they are derived are degradable. Repeat units with longer carbon backbones decreased biodegradability, though copolymers showed biodegradability at all average repeat unit lengths examined. For both homopolymers and copolymers, oxygen substitution of backbone carbons was established as a lever to improve biodegradability. A novel chemical similarity-informed embedding that considers polymer chemical structure and composition was developed and implemented for the simultaneous quantitative structure–property relationship modeling of homopolymers and copolymers. Random forest models could simultaneously capture homopolymer and copolymer behavior with 78% and 95% accuracy, respectively; however, models trained only on homopolymer data could not predict copolymer biodegradability. Unlike random forest models, linear models were not able to capture both homopolymer and copolymer biodegradability.

Citation

Macromolecules

Pub Type

Journals

Download Paper

https://doi.org/10.1021/acs.macromol.5c03562

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Keywords

biodegradability, polyesters, machine learning

Citation

Fransen, K. , Casey, J. , Godbille-Cardona, G. , Mamrol, N. , Shi, J. , Zappi, A. , Mahajan, J. , Lu, J. , Audus, D. and Olsen, B. (2026), Structure-Property Relationships for Biodegradability in Copolyesters, Macromolecules, [online], https://doi.org/10.1021/acs.macromol.5c03562, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=959951 (Accessed July 3, 2026)

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