NOTICE: Due to a lapse in annual appropriations, most of this website is not being updated. Learn more.
Form submissions will still be accepted but will not receive responses at this time. Sections of this site for programs using non-appropriated funds (such as NVLAP) or those that are excepted from the shutdown (such as CHIPS and NVD) will continue to be updated.
An official website of the United States government
Here’s how you know
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
Structure of HI1333 (YhbY), a Putative RNA-Binding Protein From Haemophilus Influenzae
Published
Author(s)
M A. Willis, W Krajewski, V R. Chalamasetty, Prasad T. Reddy, A J. Howard, O Herzberg
Abstract
The structures of a number of small [alpha]/[Beta] RNA-binding proteins with diverse biological functions are known1. Their topologies and the locations of the RNA-binding sites vary considerably, consistent with the plasticity of RNA due to base-pair mismatches, bulges and loops. Yet the protein binding surfaces can be recognized because they are enriched with positively charged residues that either form salt bridges with the negatively charged RNA or contribute favorably to the electrostatic environment. Protein regions that exhibit conformational flexibility are also good candidates for RNA-protein interactions since binding is usually accompanied by some mutual conformational adjustments1. We have determined the crystal structure of HI1333 (YhbY) from Haemophilus influenzae, a protein annotated as hypothetical in sequence databases. We propose that this protein and its close sequence relatives (25 in the non-redundant sequence database at the time of writing) comprise a new class of RNA-binding proteins.
Citation
Proteins-Structure Function And Genetics
Volume
49
Issue
No. 3
Pub Type
Journals
Keywords
function for HI1333, RNA-binding proteins
Citation
Willis, M.
, Krajewski, W.
, Chalamasetty, V.
, Reddy, P.
, Howard, A.
and Herzberg, O.
(2002),
Structure of HI1333 (YhbY), a Putative RNA-Binding Protein From Haemophilus Influenzae, Proteins-Structure Function And Genetics
(Accessed October 13, 2025)