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Solid-Phase ATRP Synthesis of Peptide-Polymer Hybrids

Published

Author(s)

Ying Mei, Kathryn L. Beers, H M. Byrd, David L. VanderHart, N. R. Washburn

Abstract

A versatile methodology for preparing hybrid biomaterials by atom transfer radical polymerization from resin-supported peptides has been established. As an example, we have synthesized a GRGDS-functionalized poly(2-hydroxyethyl methacrylate). The peptide-polymer was characterized by 1H NMR and GPC and found to have a number average molecular weight of 3900 and a polydispersity of 1.47. These values are comparable to those obtained from solution-phase syntheses, suggesting it is possible to retain significant control over the polymerization from a peptide-conjugated solid support. Solid state 13C NMR was used to characterize multiple steps in the reaction and the synthesis was found to go to near-completion. We have performed cell adhesion experiments and observed the GRGDS sequence promoted cell adhesion.
Citation
Journal of the American Chemical Society
Volume
126
Issue
No. 11

Keywords

biomaterials, polymers, synthesis

Citation

Mei, Y. , Beers, K. , Byrd, H. , VanderHart, D. and Washburn, N. (2004), Solid-Phase ATRP Synthesis of Peptide-Polymer Hybrids, Journal of the American Chemical Society, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=852269 (Accessed July 31, 2021)
Created March 1, 2004, Updated February 19, 2017