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Solid-Phase ATRP Synthesis of Peptide-Polymer Hybrids



Ying Mei, Kathryn L. Beers, H M. Byrd, David L. VanderHart, N. R. Washburn


A versatile methodology for preparing hybrid biomaterials by atom transfer radical polymerization from resin-supported peptides has been established. As an example, we have synthesized a GRGDS-functionalized poly(2-hydroxyethyl methacrylate). The peptide-polymer was characterized by 1H NMR and GPC and found to have a number average molecular weight of 3900 and a polydispersity of 1.47. These values are comparable to those obtained from solution-phase syntheses, suggesting it is possible to retain significant control over the polymerization from a peptide-conjugated solid support. Solid state 13C NMR was used to characterize multiple steps in the reaction and the synthesis was found to go to near-completion. We have performed cell adhesion experiments and observed the GRGDS sequence promoted cell adhesion.
Journal of the American Chemical Society
No. 11


biomaterials, polymers, synthesis


Mei, Y. , Beers, K. , Byrd, H. , VanderHart, D. and Washburn, N. (2004), Solid-Phase ATRP Synthesis of Peptide-Polymer Hybrids, Journal of the American Chemical Society, [online], (Accessed April 17, 2024)
Created March 1, 2004, Updated February 19, 2017