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In Situ AFM Analysis Investigating Disassembly of DNA Nanoparticles and Nano-films

Published

Author(s)

Jenifer L. Blacklock

Abstract

Synthetic vector based gene delivery continues to gain strength as viable alternatives to viral vectors due to safety and other concerns. DNA release dynamics is key to the understanding and control of gene delivery from nano-systems. Here we describe atomic force microscope (AFM) application to the understanding of DNA release dynamics from bioreducible polycation-based nano-systems. The two nano-systems are polyplex nanoparticles and layer-by-layer (LbL) films.
Citation
Nanotechnology for Nucleic acid Delivery
Volume
948
Publisher Info
Springer Publishing Company , New York, NY

Keywords

"in situ AFM", "gene delivery", "DNA release", "polyplex", "layer-by-layer (LbL)"
Created September 14, 2012, Updated November 10, 2018