Sander, L.
(2022),
Separations by Shape: Molecular Shape Recognition in Liquid Chromatography, Chromatographia, [online], https://doi.org/10.1007/s10337-022-04137-z, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=933742
(Accessed May 3, 2024)
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Separations by Shape: Molecular Shape Recognition in Liquid Chromatography
Published
Author(s)
Abstract
Molecular shape can provide a basis for chromatographic separations that is distinct from other interaction mechanisms often considered in liquid chromatography. Molecular shape recognition, or shape selectivity, is most evident for the separation of isomeric compounds that have constrained molecular structures, such as polycyclic aromatic hydrocarbons. A central feature of shape selective columns is conformational order within the stationary phase; this aspect of stationary phase morphology is revealed through spectroscopic studies and molecular dynamic simulations, and is correlated with chromatographic performance.Citation
Chromatographia
Volume
85
Pub Type
Journals
Download Paper
Keywords
Shape selectivity, conformational order, retention mechanism, isomers, stationary phase
Citation
Created February 28, 2022, Updated July 12, 2023