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Selective Streptavidin Bioconjugation on Si and SiC nanowires for Biosensor Applications.



Elissa H. Williams, John A. Schreifels, Mulpuri V. Rao, Albert Davydov, Vladimir P. Oleshko, Nancy J. Lin, Kristen L. Steffens, Sergiy Krylyuk, Kristine A. Bertness, Amy Manocchi, Yaroslav Koshka


A functionalization method for the specific and selective immobilization of the streptavidin (SA) protein on semiconductor nanowires (NWs) was developed. Silicon (Si) and silicon carbide (SiC) NWs were functionalized with 3-aminopropyltriethoxysilane (APTES) and subsequently biotinylated for the conjugation of SA. Field-emission scanning electron microscopy (FESEM), X-ray photoelectron spectroscopy (XPS), high-resolution transmission electron microscopy (HRTEM), atomic force microscopy (AFM), and fluorescence microscopy were utilized to study each functionalization step on the Si and SiC NWs.
Journal of Materials Research


biosensor, nanowires, surface chemistry


Williams, E. , Schreifels, J. , Rao, M. , Davydov, A. , Oleshko, V. , Lin, N. , , K. , Krylyuk, S. , Bertness, K. , Manocchi, A. and Koshka, Y. (2013), Selective Streptavidin Bioconjugation on Si and SiC nanowires for Biosensor Applications., Journal of Materials Research, [online], (Accessed July 19, 2024)


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Created January 14, 2013, Updated November 10, 2018