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Search Publications by: Lauren Mullen (Fed)

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Displaying 1 - 4 of 4

Variant Allele Characterization in STR Markers Using Next Generation Sequencing

May 29, 2026
Author(s)
Lauren Mullen, Carolyn Steffen, Katherine Gettings, Kevin Kiesler, Peter Vallone
Traditionally, Sanger sequencing was used to characterize reference materials and confirm discordant allele calls from different STR typing kits at the National Institute of Standards and Technology (NIST). Sequencing can also identify genomic variations

A Quantitative Method to Assess DNA Extraction Efficiency

March 15, 2026
Author(s)
Lauren Mullen, Erica Romsos, Peter Vallone
A minimum amount of extracted and purified DNA is required for a forensic short tandem repeat (STR) DNA profile to be obtained from biological samples. In most cases, this amount ranges from 0.5 to 1.0 nanograms. Certain sample types encountered in

Assessing a High Throughput SNP Assay for Closed Scenario Kinship Investigation

May 14, 2025
Author(s)
Kevin Kiesler, Carolyn Steffen, Lauren Mullen, Peter Vallone
Researchers at the U.S. National Institute of Standards and Technology (NIST) have conducted experiments using the ForenSeq Kintelligence-HT kit, a highly multiplexed single nucleotide polymorphism (SNP) panel intended for use in disaster victim

Development of Publicly Available Forensic DNA Sequence Mixture Data

March 12, 2025
Author(s)
Erica Romsos, Kevin Kiesler, Carolyn Steffen, Lisa Borsuk, Sarah Riman, Lauren Mullen, Jodi Irwin, Peter Vallone, Katherine Gettings
Background: In 2018, the Next-Generation Sequencing Committee of SWGDAM queried bioinformatic and statistical interpretation method developers regarding data needs for the development of sequence-based probabilistic genotyping software. Methods: Based on
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