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Search Publications by: Samuel Schaffter (Fed)

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Displaying 1 - 5 of 5

Experimental Evaluation of AI-Driven Protein Design Risks Using Safe Biological Proxies

June 20, 2025
Author(s)
Svetlana Ikonomova, Bruce Wittmann, Fernanda Piorino Macruz de Oliveira, David Ross, Samuel Schaffter, Olga Vasilyeva, Elizabeth Strychalski, Eric Horvitz, James Diggans, Sheng Lin-Gibson, Geoffrey Taghon
Advances in machine learning are providing new abilities for engineering biology, promising leaps forward with beneficial applications. At the same time, these advances raise concerns about biosecurity. Recently, Wittmann et al. described an in silico

Plug-and-play protein biosensors using aptamer-regulated in vitro transcription

September 12, 2024
Author(s)
Heonjoon Lee, Tian Xie, Byunghwa Kang, Xinjie Yu, Samuel Schaffter, Rebecca Schulman
Molecular biosensors that accurately measure protein concentrations without external equipment are critical for solving numerous problems in diagnostics and therapeutics. Modularly transducing the binding of protein antibodies, protein switches or aptamers

Cotranscriptionally encoded RNA strand displacement circuits

March 23, 2022
Author(s)
Samuel Schaffter, Elizabeth Strychalski
Engineered molecular circuits that process information in biological systems could address emerging human health and biomanufacturing needs. However, such circuits can be difficult to rationally design and scale. DNA-based strand displacement reactions
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