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Displaying 30726 - 30750 of 143737

Abiotic bromination of soil organic matter

October 15, 2015
Author(s)
Bruce D. Ravel, Alessandra C. Leri
Biogeochemical transformations of plant-derived soil organic matter (SOM) involve complex abiotic and microbially mediated reactions. One such reaction is halogenation, which occurs naturally in the soil environment and has been associated with enzymatic

Confidence Estimation in Stem Cell Classification

October 15, 2015
Author(s)
Peter Bajcsy, Jana Kosecka, Zahra Rajabi
We study the problem of supervised classification of stem cell colonies and confidence estimation of the attained classification labels. The problem is investigated in the application context of heterogeneity labels of stem cell colonies observed by using

Current and Emerging Technologies to Characterize the Higher-Order Structure of Monoclonal Antibodies

October 15, 2015
Author(s)
John Marino, Robert G. Brinson, Jane E. Ladner, David Travis Gallagher, Luke Arbogast, Richard Huang, Jeffrey W. Hudgens, Elyssia S. Gallagher
In contrast to small molecule therapeutics whose conformations can be absolutely defined by constitution and stereochemistry, biopharmaceuticals are distinguished by the requirement for folding into higher order structures (secondary, tertiary, and

Determination of the Primary Sequence/ Structure

October 15, 2015
Author(s)
Catherine A. Mouchahoir, Mellisa Ly, Michaella Levy, Lisa E. Kilpatrick, Scott C. Lute, Karen W. Phinney, Lisa Marzilli, Kurt A. Brorson, Michael T. Boyne, Darryl Davis, John E. Schiel
The primary sequence of a protein, including therapeutic monoclonal antibodies (mAbs), is a critical quality attribute that determines a great deal of its functionality and stability. Significant effort is devoted to determining the complete amino acid

Glycan Analysis of NIST mAb Reference Material

October 15, 2015
Author(s)
John E. Schiel, Catherine A. Mouchahoir
N-linked glycosylation is a common post-translational modification that imparts structural heterogeneity to recombinant monoclonal antibody therapeutics. The various oligosaccharides attached to the CH2 domains of IgG can impact the efficacy, safety and

Microstructural Origins of Cement Paste Degradation by External Sulfate Attack

October 15, 2015
Author(s)
Pan Feng, Edward Garboczi, Pan Feng, Jeffrey W. Bullard
A microstructure model has been applied to simulate near-surface degradation of portland cement paste in contact with a sodium sulfate solution. This new model uses thermodynamic equilibrium calculations to guide both compositional and microstructure

Multi-Scale Effects in the Strength of Ceramics

October 15, 2015
Author(s)
Robert F. Cook
Multiple length-scale effects are demonstrated in indentation-strength measurements of a range of ceramic materials under inert and reactive conditions. Meso-scale effects associated with flaw disruption by lateral cracking at large indentation loads are

Poster:A Logic Based Network Forensics Model for Evidence Analysis

October 15, 2015
Author(s)
Anoop Singhal, Changwei Liu, Duminda Wijesekera
Modern-day attackers tend to use sophisticated multi-stage/multi-host attack techniques and anti-forensics tools to cover their attack traces. Due to the current limitations of intrusion detection and forensic analysis tools, reconstructing attack

Probing Nanoscale Thermal Transport in Surfactant Solutions

October 15, 2015
Author(s)
Fangyu Cao, Ying Liu, Jiajun Xu, Yadong He, Boualem Hammouda, Rui Qiao, Bao Yang
Surfactant solutions typically feature tunable nanoscale, internal structures. Although rarely utilized, they can be a powerful platform for probing thermal transport in nanoscale domains and across interfaces with nanometer-size radius. Here, we examine

Protein Particles (0.1 ym to 100 ym)

October 15, 2015
Author(s)
Dean C. Ripple, Linda Narhi
Protein molecules in solution can form proteinaceous particles by a variety of aggregation processes. The size and concentration of these particles is an important quality attribute for therapeutic MAb solutions. In this chapter, we describe the techniques
Displaying 30726 - 30750 of 143737
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