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Bioscience / Biosecurity

Nucleic acid sequence screening

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Inter-tool analysis of a NIST dataset for assessing baseline nucleic acid sequence screening

July 10, 2025
Author(s)
Tyler Laird, Kevin Flyangolts, Craig Bartling, Bryan Gemler, Jacob Beal, Tom Mitchell, Steven T. Murphy, Jens Berlips, Leonard Foner, Ryan Doughty, Felix Qunitana, Michael Nute, Todd J. Treangen, Gene D. Godbold, Krista Ternus, Tessa Alexanian, Nicole Wheeler, Samuel Forry
Nucleic acid synthesis is a dual-use technology that can benefit fields such as biology, medicine, and information storage. However, synthetic nucleic acids could also potentially be used negligently and ultimately cause harm, or be used with malicious

Experimental Evaluation of AI-Driven Protein Design Risks Using Safe Biological Proxies

June 20, 2025
Author(s)
Svetlana Ikonomova, Bruce Wittmann, Fernanda Piorino Macruz de Oliveira, David Ross, Samuel Schaffter, Olga Vasilyeva, Elizabeth Strychalski, Eric Horvitz, James Diggans, Sheng Lin-Gibson, Geoffrey Taghon
Advances in machine learning are providing new abilities for engineering biology, promising leaps forward with beneficial applications. At the same time, these advances raise concerns about biosecurity. Recently, Wittmann et al. described an in silico
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