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Health

Cell and gene therapy

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Displaying 1 - 9 of 9

AI and Flow Cytometry

November 10, 2025
Author(s)
Dawei Lin, Anupama Gururaj, Sheng Lin-Gibson, Lili Wang
Artificial intelligence (AI) and machine learning (ML) are transforming biotechnology and playing a key role in bioeconomy. One of the most important measurement capabilities at the forefront of biotechnology innovations is flow cytometry (FCM), a high

The Need for Standardization of Extracellular Vesicle Characterization Methods

October 1, 2025
Author(s)
Bryant Nelson, Wyatt Vreeland
Extracellular vesicles (EVs) are secreted from all living organisms. The application of EVs in therapeutics, clinical diagnostics and drug delivery is expanding rapidly and the EV field is set to capitalize on this expansion through the development of next

Variability in genome-engineering source materials: Consider your starting point

March 10, 2023
Author(s)
Simona Patange, Sierra Miller, Samantha Maragh
The presence and impact of variability in cells as the source material for genome engineering are important to consider for the design, execution and interpretation of outcomes of a genome-engineering process. Variability may be present at the genotype and

Fire Burn and Cauldron Bubble: What is in your Genome Editing Brew?

October 28, 2022
Author(s)
Simona Patange, Samantha Maragh
Genome editing is a rapidly evolving biotechnology with the potential to transform many sectors of industry such as agriculture, biomanufacturing, and medicine. This technology is enabled by an ever-growing portfolio of biomolecular reagents that span the

The NIH Somatic Cell Genome Editing program

April 7, 2021
Author(s)
Samantha Maragh
The move from reading to writing the human genome offers new opportunities to improve human health. The United States National Institutes of Health (NIH) Somatic Cell Genome Editing (SCGE) Consortium aims to accelerate the development of safer and more

THE GUT MICROBIOME AND XENOBIOTICS: IDENTIFYING KNOWLEDGE GAPS

July 1, 2020
Author(s)
Vicki L. Sutherland, Charlene A. McQueen, donna Mendrick, donna gulezian, Carl Cerniglia, Steven Foley, Samuel Forry, Sangeeta Khare, Xue Liang, Jose E. Manautou, Donald Tweedie, howard young, Alexander Aleksenkyo, frank burns, Rod Dietert, Katherine Karberg, alan wilson, connie chen
There is an increasing awareness that the gut microbiome plays a critical role in human health and disease, but mechanistic insights are often lacking. In June 2018, the Health and Environmental Sciences Institute (HESI) held a workshop, "The Gut

Regulation of Oxygen Level and Pervaporation in Microfluidic Devices

October 13, 2011
Author(s)
Peter C. Thomas, Srinivasa R. Raghavan, Samuel Forry
Oxygen level plays a critical role in maintaining cell homeostasis. Misregulation of oxygen levels in cell culture have been shown to impact cell growth, death and differentiation. As such, proper management of oxygen level is required in cell based assays
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