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The presence and impact of variability in cells as the source material for genome engineering are important to consider for the design, execution and interpretation of outcomes of a genome-engineering process. Variability may be present at the genotype and
Genome editing is a rapidly evolving biotechnology with the potential to transform many sectors of industry such as agriculture, biomanufacturing, and medicine. This technology is enabled by an ever-growing portfolio of biomolecular reagents that span the
Sarah Inwood, Linhua Tian, Kirsten Parratt, Samantha Maragh, Lili Wang
CRISPR/Cas9, one of the most commonly used genome editing systems, has been used for production of protein, cell and gene therapies. While an exciting tool, there is not a lot of long-term data about its genomic and phenotypic stability and off-target
The move from reading to writing the human genome offers new opportunities to improve human health. The United States National Institutes of Health (NIH) Somatic Cell Genome Editing (SCGE) Consortium aims to accelerate the development of safer and more
Samantha Maragh, Natalia G. Kolmakova, Evgheni Strelcov
Current methods can illuminate the genome-wide activity of CRISPR–Cas9 nucleases, but are not easily scalable to the throughput needed to fully understand the principles that govern Cas9 specificity. Here we describe 'circularization for high-throughput