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Recent Developments in Y STR and Y SNP Analysis



John Butler


This article reviews new genetic markers on the Y chromosome and methods for analyzing these short tandem repeat (STR) and single nucleotide polymorphism (SNP) loci. Relative chromosomal locations for over 50 Y STRs are described along with their repeat motif and allele range characteristics based on published population studies. Multiplex assays for typing many of these markers in a parallel fashion are mentioned, as are newly available commercial Y STR kits. Approximately 250 SNP markers are now cataloged along the Y chromosome with a unified haplogroup nomenclature describing the markers relative relationships. Technologies for typing these SNPs are reviewed including primer extension and allele-specific hybridization methods. Finally, available reference materials for standardization of allele calls, Y STR allele nomenclature issues, and published validation and interlaboratory studies are reviewed.
Forensic Science International


forensic DNA typing, Luminex, multiplex PCR, SNaPshot, standard reference materials, STR nomenclature issues, Y chromosome, Y SNP, Y STR


Butler, J. (2008), Recent Developments in Y STR and Y SNP Analysis, Forensic Science International (Accessed April 23, 2024)
Created October 16, 2008