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Realization and dissemination of activity standards for medically important alpha-emitting radionuclides

Published

Author(s)

Denis E. Bergeron, Karsten Kossert, Sean Collins, Andrew Fenwick

Abstract

Interest in targeted cancer therapy with alpha-emitting radionuclides is growing. To evaluate emerging radiotherapeutic agents requires precise activity measurements for consistent dose-response relationships and patient-specific dosimetry. National metrology institutes around the world have reported on the development and comparison of activity standards for medically important alpha-emitters. This review describes the relevant methods and models underpinning these standards, the generation of new nuclear decay data, and the impacts on preclinical and clinical activity assays using radionuclide calibrators and gamma-ray spectrometry.
Citation
Applied Radiation and Isotopes
Volume
184

Citation

Bergeron, D. , Kossert, K. , Collins, S. and Fenwick, A. (2022), Realization and dissemination of activity standards for medically important alpha-emitting radionuclides, Applied Radiation and Isotopes, [online], https://doi.org/10.1016/j.apradiso.2022.110161, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=934015 (Accessed November 29, 2022)
Created March 4, 2022, Updated March 11, 2022