Reactions of the Amine-Containing Drugs Fluoxetine and Metoprolol During Chemical Processes Used in Wastewater Treatment
Mary Bedner, William A. MacCrehan
The reactivity of the amine containing pharmaceuticals fluoxetine and metoprolol with hypochlorite were studied using conditions that simulate wastewater disinfection including neutral pH (7.0), a range of reaction times (2 60 min), and a molar excess of hypochlorite relative to the pharmaceutical concentration (5.7 times). The reactions were monitored using liquid chromatography (LC) with several detection modes including ultraviolet absorbance (UV), mass spectrometry (MS), and post-column reaction/reductive electrochemistry for determining active chlorine products. At levels of 10 umol/L, both compounds reacted rapidly (
and MacCrehan, W.
Reactions of the Amine-Containing Drugs Fluoxetine and Metoprolol During Chemical Processes Used in Wastewater Treatment, Chemosphere, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=832123
(Accessed October 4, 2023)