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Reactions of the Amine-Containing Drugs Fluoxetine and Metoprolol During Chemical Processes Used in Wastewater Treatment

Published

Author(s)

Mary Bedner, William A. MacCrehan

Abstract

The reactivity of the amine containing pharmaceuticals fluoxetine and metoprolol with hypochlorite were studied using conditions that simulate wastewater disinfection including neutral pH (7.0), a range of reaction times (2 60 min), and a molar excess of hypochlorite relative to the pharmaceutical concentration (5.7 times). The reactions were monitored using liquid chromatography (LC) with several detection modes including ultraviolet absorbance (UV), mass spectrometry (MS), and post-column reaction/reductive electrochemistry for determining active chlorine products. At levels of 10 umol/L, both compounds reacted rapidly (
Citation
Chemosphere
Volume
95

Keywords

chloramine, chlorine, dechlorination, disinfection, pharmaceutical, wastewater

Citation

Bedner, M. and MacCrehan, W. (2006), Reactions of the Amine-Containing Drugs Fluoxetine and Metoprolol During Chemical Processes Used in Wastewater Treatment, Chemosphere, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=832123 (Accessed July 3, 2022)
Created July 25, 2006, Updated February 17, 2017