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Quantitative, Interactive Measurement of Tissue Engineering Scaffold Structure Using Immersive Visualization

Published

Author(s)

Jeffrey Fagan, Erik K. Hobbie, Brian Landi, Idan Mandelbaum, Vardhan Bajpai, Barry J. Bauer, Kalman D. Migler, Jeffrey R. Simpson, Angela R. Hight Walker, Ryan Raffaelle

Abstract

At NIST, we are using new approaches to better understand and quantify the structure of tissue engineering scaffolds. This approach uses immersive visualization (IV) and is inherently three dimensional, multivariate and interactive, providing real-time measurements of scaffold descriptors along with visualizing their locations within the scaffold. In this initial implementation of quantitative IV, we take a series of measurements on candidate geometric reference scaffold manufactured by solid freeform fabrication (SFF) with a 0o/60o/120o lay-down pattern.Using custom written algorithms, many descriptors about scaffold structure are extracted. These include, but are not limited to, strut width and eccentricity, anisotropy in strut width, center-to-center distance between struts (in-plane and between planes), edge-to-edge distance between struts (in-plane and between planes), angles between struts, and planarity of horizontal and vertical layers of fibers. Inherent in the IVE is the ability to display the each type of result in histogram form with statistical analysis. The scientist can then highlight bins of interest in the histogram and have the locations of those results highlighted within the scaffold. This provides a visual means to assess quality and isotropy of the scaffold. The results are compared to those from the as-designed scaffold to evaluate the manufacturing process.
Proceedings Title
New Jersey Symposium on Biomaterials Science | 8th | | The New Jersey Center for Biomaterials
Volume
110
Conference Dates
November 8-10, 2006
Conference Location
Undefined
Conference Title
New Jersey Symposium on Biomaterials Science Proceedings

Keywords

scaffolds

Citation

Fagan, J. , Hobbie, E. , Landi, B. , Mandelbaum, I. , Bajpai, V. , Bauer, B. , Migler, K. , Simpson, J. , Hight Walker, A. and Raffaelle, R. (2006), Quantitative, Interactive Measurement of Tissue Engineering Scaffold Structure Using Immersive Visualization, New Jersey Symposium on Biomaterials Science | 8th | | The New Jersey Center for Biomaterials, Undefined, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=852639 (Accessed June 10, 2023)
Created December 31, 2005, Updated October 12, 2021