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Quantitation of Polymer End Groups Using MALDI TOF MS



A P. Weaver, Charles M. Guttman, Kathleen M. Flynn


Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI TOF MS) has been employed to analyze polystryrene mixtures of molecular mass ca. 4000u. The component polymers of thes mixtures are identical except for their end groups. MALDI TOF MS with time-lag focusing (delayed extraction) enables sufficient resolution for the quantitation of polymer mixtures by giving the structural information of individual oligomeric species within the samples studied. The mass fractions of polystyrene (PS) and monohydroxy-terminated polystyrene (PSOH) were varied and analyzed by MALDI TOF MS using 2,5-dihydroxybenzoic acid (DHB), dithranol, all-trans retinoic acid, and trans-1,4-diphenyl-1,3-butadiene matrices. The relative amount of each type of polystyrene contained in the samples has been inferred by computing the peak areas from the mass spectral data.By comparing the ratios obtained by computing the MALDI peak areas to the mass fractions of the components the results show that the MALDI data does not accurately represent the mass fractions of the components in the mixtures.
Proceedings Title
Polymer poster session at the 50th annual conference on Mass Spectrometry
Conference Dates
July 1, 2002
Conference Location
Orlando, FL
Conference Title
ASMS Conference on Mass Spectrometry


MALDI, polystyrene, quantitative analysis


Weaver, A. , Guttman, C. and Flynn, K. (2002), Quantitation of Polymer End Groups Using MALDI TOF MS, Polymer poster session at the 50th annual conference on Mass Spectrometry, Orlando, FL, [online], (Accessed May 30, 2024)


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Created June 30, 2002, Updated October 12, 2021