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Production and Analysis of RM 8403 Cocoa Flavanol Extract



Catherine A. Rimmer, Katrice A. Lippa, James H. Yen, Ugo Bussy, Gregory Hewitt, Nicholas P. Anderson, Catherine Kwik-Uribe


NIST Reference Material 8403 is intended for use in harmonizing methods for the determination of cocoa flavanols monomers and their oligomers up to a degree of polymerization (DP) of 7 units. RM 8403 is a free-flowing powder containing cocoa flavanols sealed in aluminized mylar sachets. A unit of RM 8403 consists of five sachets each containing approximately 3 g of the cocoa extract powder. This publication documents the production, measurement results, and statistical analysis in realizing this product.
Special Publication (NIST SP) - 260-207
Report Number


catechin, epicatechin, procyanidin, cocoa, degree of polymerization (DP), flavanol, NIST Reference Material (RM)


Rimmer, C. , Lippa, K. , Yen, J. , Bussy, U. , Hewitt, G. , , N. and Kwik-Uribe, C. (2020), Production and Analysis of RM 8403 Cocoa Flavanol Extract, Special Publication (NIST SP), National Institute of Standards and Technology, Gaithersburg, MD, [online], (Accessed May 29, 2024)


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Created October 22, 2020, Updated October 28, 2020