U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PUBLICATIONS

Probing Pluripotency Gene Regulatory Networks with Live Cell Imaging

Published

Author(s)

Anne L. Plant, Michael W. Halter, Jeffrey R. Stinson

Abstract

Although live cell imaging has not been often used in the study of gene regulatory networks, it is a method that uniquely enables the measurement of dynamic events in single cells. Dynamical information about network components and their interactions is critical to predictive modeling of gene regulatory networks, and is currently not accessible through omics and other end point techniques. In this brief review we discuss the importance of dynamics to network modeling, and recent advances in imaging and genetic engineering technologies that are making the use of imaging for network analysis possible.
Citation
Computational and Structural Biotechnology Journal
Pub Type
Journals

Keywords

systems biology, live cell imaging, gene regulatory networks, Langevin equation
Modeling and simulation research and Cell biology

Citation

Plant, A. , Halter, M. and Stinson, J. (2020), Probing Pluripotency Gene Regulatory Networks with Live Cell Imaging, Computational and Structural Biotechnology Journal (Accessed September 23, 2021)

Created June 30, 2020