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Probing the Location of the Terminal Groups of Dendrimers in Dilute Solution



A Topp, Barry J. Bauer, J W. Klimash, R Spindler, D A. Tomalia, Eric J. Amis


The spatial distribution of the terminal groups of poly (amido amine) dendrimers have been determined experimentally by small angle neutron scattering with deuterium labeling and scattering contract variation. The radius of gyration of deuterated terminal units of generation 7 dendrimers is (39.3 1.0) D. This is significantly larger than the radius of gyration of the whole dendrimer, which is (34.4 0.2) D. This data indicates that dendrimers have terminal groups that are concentrated near the periphery. These results are inconsistent with many computer simulations and some molecular models.
No. 21


contrast match, dendrimer, PAMAM, radius of gyration, SANS, terminal group


Topp, A. , Bauer, B. , Klimash, J. , Spindler, R. , Tomalia, D. and Amis, E. (1999), Probing the Location of the Terminal Groups of Dendrimers in Dilute Solution, Macromolecules, [online], (Accessed April 19, 2024)
Created October 1, 1999, Updated February 17, 2017