NOTICE: Due to a lapse in annual appropriations, most of this website is not being updated. Learn more.
Form submissions will still be accepted but will not receive responses at this time. Sections of this site for programs using non-appropriated funds (such as NVLAP) or those that are excepted from the shutdown (such as CHIPS and NVD) will continue to be updated.
An official website of the United States government
Here’s how you know
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
Preliminary Report on the Biocompatibility of a Moldable, Resorbable, Composite Bone Graft Consisting of Calcium Phosphate Cement and Poly (Lactide-Co-Glycolide) Microspheres
Published
Author(s)
Carl Simon Jr., C A. Khatri, Scott Wight, Francis W. Wang
Abstract
We have assessed the biocompatibility of a new composite bone graft consisting of calcium phosphate cement (CPC) and poly(lactide-co-glycolide) (PLGA) microspheres (175-350 ?m) using cell culture techniques. CPC powder is mixed with PLGA microspheres and water to yield a workable paste that can be sculpted to fit the contours of a wound. The cement then hardens into a matrix of hydroxyapatite microcrystals containing PLGA microspheres. The microspheres initially stabilize the graft but will gradually degrade leaving behind pores for colonization by osteoblasts. The CPC matrix can then be resorbed and replaced with new bone. Previously, we assessed the mechanical properties and in-vitro degradation of the composite bone graft. In the present study, osteoblast-like cells were seeded onto graft specimens and observed with fluorescence microscopy and environmental scanning electron microscopy. Cells were able to adhere and attain a normal morphology when cultured on the composite (CPC-PLGA) and control (CPC alone) grafts suggesting that our new cement consisting of CPC and PLGA microspheres is biocompatible.
Simon Jr., C.
, Khatri, C.
, Wight, S.
and Wang, F.
(2002),
Preliminary Report on the Biocompatibility of a Moldable, Resorbable, Composite Bone Graft Consisting of Calcium Phosphate Cement and Poly (Lactide-Co-Glycolide) Microspheres, Journal of Orthopaedic Research, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=851741
(Accessed October 2, 2025)