Polymer Matrix Effects on the Properties of Amorphous Calcium Phosphate-Filled Composites

Published

April 1, 2001

Author(s)

Drago Skrtic, Joseph M. Antonucci, D E. Eanes

Abstract

Calcium phosphate are funding increasing use as biomaterials, e.g. in the treatment of defective mineralized tissues. Crystaline hydroxyapatite (HAP) is considered to be the final stable product in the precipitation of calcium and phosphate ions from neutral or basic solutions and it is also the structural prototype of the major mineral component of bones and teeth. Over the broad range of solution conditions when precipation occurs spontaneously, amorphous calcium phosphate (ACP) precedes the formation of HAP. ACP, a plausible key precursor in_the biological formation of HAP, is characterized by a high degree of aqueous solubility and facile conversion to HAP, particularly at low pHs (1). These properties, undesirable for applications where structural, mechanical and chemical stabilities are desired, make ACP suitable as a remineralizing agent. We have recently shown (2) that a new class of polymeric composite materials can be formulated that utilize ACP as a filler with dental monomers such as 2,2-bis[p-(2' hydroxy-3'-methacryloxypropoxy)phenyl]propane (Bis-GMA), triethylene glycol dimethacrylate (TEGDMA), and 2-hydroxyethyl methacrylate (HEMA). Previous studies have shown that certain variations in methacrylate resin chemical structure and composition may affect the rate and extent of the ion release from ACP-filled composites, the internal conversion of ACP into HAP and the mechanical properties of the the composites (4,5). The objective of this study was to further explore the effects of the chemical structure and compositional variations of the resins on the release of mineral ions (Ca²⁴ and phosphate). The resins included those previously examined and other types of resin matrices that include urethane dimethacrylate (UDMA), and a carboxylic acid-contining monomer, pyromellitic glycerol dimethacrylate (PMGDMA). The effect of adding a potential coupling agent such as zirconyl methacrylate (ZrMA0 was also investigated.

Proceedings Title

American Chemical Society; Division of Polymer Chemistry, Meeting | | | American Chemical Society (ACS)

Volume

41

Issue

No. 2

Conference Dates

August 20-24, 2000

Conference Title

Polymer Preprints

Pub Type

Conferences

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Keywords

amorphous calcium phosphate, ion release, polymer matrix, remineralization

Citation

Skrtic, D. , Antonucci, J. and Eanes, D. (2001), Polymer Matrix Effects on the Properties of Amorphous Calcium Phosphate-Filled Composites, American Chemical Society; Division of Polymer Chemistry, Meeting | | | American Chemical Society (ACS), [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=851701 (Accessed April 26, 2024)