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Polymer-Filled Calcium Phosphate Cement: Mechanical Properties and Controlled Release of Growth Factor

Published

Author(s)

Francis W. Wang, C A. Khatri, J F. Hsii

Abstract

Calcium phosphate cement (CPC) was improved by incorporating porogens to induce macropores and proteins to stimulate bone growth. A paste was made from CPC powder (0.15 g equimolar mixture of tetracalcium phosphate and dicalcium phosphate anhydrous), degradable polymer microspheres [0.1 g, 0.6 volume fraction, (0.17 to 0.36) mm dia.], and 0.062 g water. Discs for diametral tensile strength (DTS) were prepared by applying a 20 N load on the paste in a mold at 37 C. Discs for the release of Protein A (a model for growth factors) were similarly prepared, using the microspheres (0.6 volume fraction) or mannitol crystals (0.0, 0.35 or 0.60 volume fraction) as porogens, and a Protein-A solution. Discs for DTS and protein release were stored at 37 C in aqueous solutions for 24 h.Mechanical properties and mass loss experiments showed that there was very little decrease in the mass of the composite during the first four weeks, but there was a steady decrease in DTS during this period. The release rate of Protein A from CPC/mannitol discs increased with mannitol volume fraction. Thus, the release of proteins from composite grafts can be modulated by the volume fraction and the dissolution rate of porogens.
Proceedings Title
Southern Biomedical Engineering Conference | 21st | | Medical and Engineering Publishers
Volume
55
Conference Dates
September 1, 2002
Conference Title
Biomedical Engineering

Keywords

bone grafts, calcium phosphate cements, controlled release, poly(d, l-lactide), poly(d, l-lactide-co-glycolide)

Citation

Wang, F. , Khatri, C. and Hsii, J. (2002), Polymer-Filled Calcium Phosphate Cement: Mechanical Properties and Controlled Release of Growth Factor, Southern Biomedical Engineering Conference | 21st | | Medical and Engineering Publishers, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=852086 (Accessed July 17, 2024)

Issues

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Created November 1, 2002, Updated February 17, 2017